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【生醫】(回顧文)電紡絲用在傷口癒合的應用
最新消息 - 2018/4/12
傷口癒合是一個複雜的組織再生過程，促進新的增長組織為身體提供來自外部環境的必要屏障。
在所有可用的現有技術中，靜電紡絲纖維可能具有幾個特徵為傷口提供新穎的替換敷料材料。
因此，在這介紹了靜電紡絲藥物洗脫纖維在傷口癒合方面的最新應用。特別是藥物釋放，
包括小分子藥物，蛋白質和藥物肽和來自電紡纖維的基因載體關於傷口癒合。
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Figure 3. (a) Wound healing of a diabetic mouse (DM) model for comparison of effects on delivery of
EGF cDNA and VEGF cDNA after 6 days; (b) Percent wound closure after receiving gene therapy from
the mouse model; (c) Histology of the wound tissues from the animal model where tissues receiving
EGF and VEGF showed restoration of the tissue structure [135]. Figures were obtained from an open
access article distributed under the Creative Commons Attrib
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Figure 4. (a) Diabetic skin wound using a rat model for comparison of control and those subjected to
delivery of pbFGF polyplexes from electrospun poly(ethylene imine)/PEG (2 kDa) core/shell fibers
(Fa2: blank fibers and Fb2: fibers with pbFGF polyplexes in the core); (b) In vitro release profiles of
pbFGF from electrospun poly(ethylene imine)/PEG core/shell fibers (Fb2: 2 kDa PEG and Fb4: 4 kDa
PEG); (c) Percentage of wound area from the diabetic rat model [143]. Reprinted with permission from
American Chemical Society. Copyright (2017) American Chemical Society.
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Ref. “Electrospun Fibers as a Dressing Material for Drug and Biological Agent Delivery in
Wound Healing Applications”(2018) Bioengineering