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【生醫】(回顧文)電紡絲用在人造血管

最新消息 - 2018/5/18

小直徑血管(SDBV)發生內膜增生和動脈瘤擴張而造成的血栓，要解決此問題是一個艱鉅的任務。

靜電技術作為一種有前途的組織工程方法，可以製造聚合物纖維支架滿足對天然血管和細胞外基

質（ECM）構建的要求促進細胞的粘附，增殖和生長。在這篇綜述中，總結了這些聚合物用於製

造SDBV並將其分為三類，合成類聚合物，天然聚合物和雜化聚合物。

Figure 1. Schematic illustration of blood vessel structure (reprinted from Ref. [16]).

Figure 2. Electrospinning setups: (a) grounded flat collector is used to collect fibers; (b) tubular

rotating mandrel is used to collect fibers to shape blood vessels.

Figure 3. SEM photographs of (a) synthetic poly(ε-caprolactone) (PCL)/Poly(l-lactic acid) (PLA)

blood vessel of 6 mm diameter, (b) the randomly oriented PCL fiber inner layer, (c) the aligned

PLA fiber outer layer (reprinted from Ref. [34]).

Figure 5. Tubular blood vessels fabricated by melt electrospinning: (a,b) polypropylene (Moplen

462R PP); (c,d) polylactide (PLA 4060D) (reprinted from Ref. [42]).

Figure 9. Expression of transgene eNOS protein in both MSCs seeded blood vessel (a,b) and

eNOS-MSCs seeded blood vessel (c,d) (reprinted from Ref. [84]).

Figure 11. Investigation of explanted (a) PCL graft and (b) PCL-arginine-glycine-aspartic acid

(RGD) graft by stereomicroscope and (c,d) cross-section staining after four weeks of implantation.

Acute thrombosis was observed in the lumen of PCL (reprinted from Ref. [89]).

Ref. “Electrospun Fibrous Scaffolds for Small-Diameter Blood Vessels: A Review”(2018) Membranes